We are looking for a highly motivated MSc student (m/f/x) to join our proteomics method development team to develop a low input & high throughput interactomics pipeline.
Our Group. At the Proteomics Tech-Hub, we aim to develop new and powerful methods to increase sensitivity in protein identification, accuracy and precision of protein quantification or post-translational modification detection. We establish comprehensive strategies in the field of crosslinking mass spectrometry to gain insights in structural biology and model protein-protein interaction surfaces. Furthermore, single cell proteomics, multiomic technologies and spatial omics are among our research interests. Our cutting-edge method development strategies are ranging from sample preparation to optimization of data acquisition, data analysis and validation. To achieve these goals, we frequently collaborate with international research groups and industry. The group is equipped with state of art MS, and liquid chromatography as well as sample preparation robotics instrumentation.
The Project. The successful candidate will be part of the research team involved in establishing novel crosslink mass spectrometry pipelines aiming to stabilise transient interaction partners and enrich those stabilised protein complexes by affinity purification. The project aims to downscale (limited) input material and to apply high order multiplexing allowing to boost throughput. Within the project we will screen a large library of oligopeptides for their interaction with a selected subset of proteins. We will make use of AI-powered tools to predict and model interaction surfaces aiming to understand molecular pathways underlying the regulation of gene expression in response to developmental or environmental stimuli and understand the role of transcription factor and cofactor proteins that mediate transcription activation.
The Candidate. The successful candidate should hold a BSc degree in the fields of chemistry, biochemistry, molecular biology or a related field. Experience in mass spectrometry as well as in the wet lab are not mandatory but considered a plus. The candidate should be curious, creative and excited about learning new topics and skills! Fluency in English is required. Despite the emphasis on technology development within our group, a candidate with experience, knowledge or curiosity at the interception of analytical chemistry and biochemistry will make a perfect match.
Our Environment. The Research Institute of Molecular Pathology (IMP) in Vienna is a basic biomedical research institute largely sponsored by Boehringer Ingelheim. With over 200 scientists from 40 countries, the IMP is committed to scientific discovery of fundamental molecular and cellular mechanisms underlying complex biological phenomena. The IMP is embedded within the Vienna BioCenter, one of Europe’s most dynamic life science hubs with more than 3,000 employees from 80 countries in six research institutions, two universities and two dozen biotech companies.
The proposed project is scheduled to be completed within one year and the successful candidate will be enabled to complete their master’s thesis within this project. The position is open from summer 2025 and remains open until filled. The successful applicant will receive a monthly stipend.
Please send your application (motivation letter, CV, contact details of at least one reference) by mail to karl.mechtler[at]imp.ac.at and manuel.matzinger[at]imp.ac.at
Please note that we do not offer a full master program. Applicants will need to enroll or be enrolled in a master program that allows for research to be conducted at external institutions.